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#Repost @tcichemicals
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“Golden Rain" is the reaction of #potassium #iodide and #lead(II) #nitrate. On their own, they're quite stable, but when combined they come together to create a beautiful golden snowglobe! Its #NationalChemistryWeek: what are some of your favorite reactions?
#chemistry #science #chemicalreaction #chemicalreactiongifs #beautifulchemistry
#fluorescencefriday ☺ #science #germanscienceguy #chemistry #ochem #beautifulchemistry #scientist #organic #chemical #chemist #solution #reaction #research #blue #flask #lab #instachem #laboratory #biochemistry #organicchemistry #photography #photo #colorful #chemistrylab #quimica #student #university #chemie #giessen
مثل نیکل در دمای 150 درجه سانتی گراد باشیم:))
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#science #chemistry #chemistryjokes #chemists #chemist #chemistrymemes #chemistrylove #chemistrylover #chemistrylovers #pcmb #pcmbmemes #chemistrylab #chemistrylab #chemistrylaboratory #chemistrymajor #organicchemistry #inorganicchemistry #chemicals
#laboratory #labchem #chemlab #laboratoryglass #organic #Inorganic #analytical #physicalChemistry #Reaction #beautifulChemistry
Just doing a column of my final product.
#fluorescentfriday
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Repost @cell_bones - such an awesome instagram feed!
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This movie shows a molecular dynamics simulation of the protein MdmX in complex with a small molecule inhibitor, 298, otherwise known as
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4-[[(4S,5R)-5-(4-chlorophenyl)-4-(3-methoxyphenyl)- 2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5- dihydroimidazol-1-yl]carbonyl]piperazin-2-one
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The inhibitor is shown as light, medium and dark pink spheres, and the MdmX protein is shown as red, blue, white, purple and yellow spheres. The colored spheres represent the individual atoms: White is hydrogen, blue carbon, red oxygen, purple nitrogen, and yellow sulfur.
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The protein MdmX normally regulates the tumor suppressor protein, p53, by binding to it and preventing it from its functions in halting the cell cycle, repairing damaged DNA and inducing programmed cell death.
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In some cancers, p53 activity is reduced by overexpression of MdmX, and this allows tumors to escape the p53-triggered cell death. To help restore p53 activity in these types of cancers, research has focused on finding inhibitors of MdmX.
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The compound 298 was found in a search for small molecules that inhibit the MdmX-p53 interaction. Even though 298 binds to MdmX relatively weakly, it is able to overcome the inhibition of p53 in retinoblastoma cell lines where MdmX is overexpressed. This is a promising avenue for the search for additional inhibitors of MdmX.
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The structure file for this complex (2n06) can be found at http://www.rcsb.org/pdb/explore/explore.do?structureId=2N06. The reference for the publication is Grace et al. (2016) Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol. 428: 1290-1303.
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The molecular dynamics simulation (10 picoseconds) was done using the program Chimera. The resulting trajectory was colored in PyMOL and ray traced using POV-Ray. The video was made using the program ffmpeg.
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#chemistry #molecule #molecularstructure #biochemistry #pymol #instascience #3dmodel #structure #protein #organicchemistry #cellbiology #molecularstructure # #moleculardynamics #ILoveScience #science #biology #cancer #rendering #molekül #chemie #sciart #quimica #beautifulchemistry
Very cute schlenk line ❤ ⌬
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#science #germanscienceguy #chemistry #ochem #cute #beautifulchemistry #scientist #organic #chemical #chemist #solution #reaction #research #red #flask #lab #instachem #laboratory #biochemistry #organicchemistry #photography #photo #colorful #chemistrylab #quimica #student #university #chemie #giessen #unigiessen